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Most symptomatic children with biotinase deficiency exhibit serum biotinase activity at 10% of normal levels or undetectable, and biotin levels in the brain and CSF are typically even lower [72]

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Sodium-glucose transport protein 2 (SGLT2) inhibitors Primary mechanism(s) of action Reduce reabsorption of glucose in the kidneys (renal tubules) by inhibiting sodium-glucose transport protein 2 (SGLT2)